New Research Unveils Key Dynamics in Melanoma Cells Post UV Exposure
SiSP latest study, published in Free Radical Biology and Medicine, presents insights into how melanoma cells respond to UV radiation and phytochemicals. By utilizing live-cell imaging and our newly developed reporter, we've observed the specific activation patterns of Nuclear factor erythroid 2-related factor 2 (Nrf2), a crucial player in cell defense mechanisms. This work underscores the potential of Nrf2 as a target for antioxidant compound screening, paving the way for innovative cancer treatment strategies.
“This is the first time we developed the Nrf2 biosensor that can reveal the complex dynamics of Nrf2 activation in response to various environmental stimuli. Our sensor system would serve as a novel and promising technology that could be exploited for the discovery and development of pharmacological interventions targeting Nrf2 in conditions associated with photooxidative stress.”
“This is the first time that we can observe how NRF2 dynamics vary with the different phytochemicals. This work will be useful for screening novel antioxidant compounds from natural products, as well as for studying the roles of NRF2 in different diseases.”
Read the original article at https://doi.org/10.1016/j.freeradbiomed.2023.12.007.
